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Medchemexpress LLC Butyrolactone 3 | 778649-18-6 | 99.6% | 25 MG
Supplier: Medchemexpress LLC 25MGHY129039
Butyrolactone 3 (MB-3) is a specific small-molecule inhibitor of the histone acetyltransferase Gcn5, demonstrating an IC50 of 100 μM. It shows high affinity for the Gcn5 enzyme, similar to its natural substrate histone H3, while exhibiting weak inhibitory activity on CBP (IC50=0.5 mM). This compound is valuable for research in cancer, metabolic, autoimmune, and neurological diseases.
- Specific small-molecule inhibitor of histone acetyltransferase Gcn5
- High affinity for the Gcn5 enzyme
- Weak inhibitory activity on CBP
- Useful in studies related to cancer, metabolic, autoimmune, and neurological diseases
- Reduces Gcn5 acetylation
- Induces E2A-PBX1 degradation
- Decreases protein levels of E2A-PBX1, E2A, Wnt16, and GCN5 in RCH-ACV cells
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