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AdipoGen Butyrolactone I

Supplier: AdipoGen BVT0448M001
Chemical. CAS 87414-49-1. Formula C24H24O7. MW 424.5. Isolated from Aspergillus terreus. Cell permeable, potent and selective cyclin-dependent kinase CDK-1 CDC2, -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs. Inhibitor of alpha-glucosidases. Maturation inhibitor of sheep oocytes.
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