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Medchemexpress LLC BX430 | 688309-70-8 | 99.2% | 413.11 | 1 ML
SDP

Catalog No. 5000343837
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BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. It exhibits species specificity and is used for chronic pain and cardiovascular disease.

  • Has virtually no functional impact on all other P2X subtypes (P2X1-P2X3, P2X5, and P2X7).
  • Potent antagonist of zebrafish P2X4.
  • Reduces intracellular calcium rise evoked by ATP in human P2X4-expressing cells.
  • Markedly reduces the amplitude of ATP-evoked intracellular calcium responses in THP-1 cells.

Catalog No. 50-003-43837 Supplier Medchemexpress LLC Supplier No. HY11023710MG
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BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. It exhibits species specificity and is used for chronic pain and cardiovascular disease.

  • Has virtually no functional impact on all other P2X subtypes (P2X1-P2X3, P2X5, and P2X7).
  • Potent antagonist of zebrafish P2X4.
  • Reduces intracellular calcium rise evoked by ATP in human P2X4-expressing cells.
  • Markedly reduces the amplitude of ATP-evoked intracellular calcium responses in THP-1 cells.

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