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Apexbio Technology LLC BX795 702675-74-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A82225.1
BX795 (CAS 702675-74-9) is a small-molecule inhibitor targeting 3-phosphoinositide-dependent kinase-1 (PDK1) through ATP-competitive binding inhibiting its enzymatic activity with an IC50 of approximately 11 nM Additionally BX795 selectively inhibits TBK1 and IKK with reported IC50 values of 6 nM and 41 nM respectively In macrophages activated by poly(I C) and LPS BX795 suppresses TBK1/IKK -mediated interferon regulatory factor-3 (IRF3) phosphorylation nuclear translocation transcriptional activity and consequent interferon- production This compound is utilized in biomedical research examining kinase signaling pathways and innate immune responses
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