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Medchemexpress LLC C-82 | 1422253-37-9 | 99.9% | 578.66 | 1 MG
Supplier: Medchemexpress LLC HY1123591MG
C-82 is a second-generation specific CBP/β-catenin antagonist. It functions by inhibiting the binding between β-catenin and CBP, while simultaneously increasing the binding between β-catenin and p300. C-82 is the active form of PRI-724, which is rapidly hydrolyzed to C-82 in vivo and has shown an acceptable toxicity profile in preclinical studies.
- Inhibits CBP/β-catenin binding.
- Increases β-catenin/p300 binding.
- Inhibits activation of quiescent hepatic stellate cells (HSCs).
- Promotes cell death in culture-activated HSCs.
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