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Eurofins Discoverx c-Kit (V654A), active, 10 µg. (14-733)
Supplier: Eurofins Discoverx 14733
N-terminal GST-tagged recombinant, human c-Kit amino acids 544-end containing the V654A mutation. Co-ordinates encompass the cytoplasmic domain (544-976) according in Swiss-Prot P10721. V654A is an acquired resistance mutation which has been found in patients with gastrointestinal stromal tumors (GISTs) undergoing treatment with Imatinib. The V654A mutation is strongly correlated with Imatinib resistance and rapid progression of GISTs. (Chen LL et al., Cancer Research, (2004); 64:5913-5919). For detailed product information, visit www.discoverx.com/proteins.
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