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Medchemexpress LLC C12-200 | 1220890-25-4 | 99.9% | C70H145N5O5 | 100 MG
Supplier: Medchemexpress LLC HY145405100MG
C12-200 is an ionizable cationic lipid and helper lipid primarily used for mRNA delivery. It has been successfully utilized to deliver and express mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) in hemophilia B mouse models, making it a valuable tool for research related to hemophilia B.
- Used for mRNA delivery.
- Delivers and expresses mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX).
- Utilized in hemophilia B research models.
- Produces target proteins at supraphysiological levels from exogenous human mRNA.
- Demonstrates potent pharmacodynamic effects in KO mouse models.
- Achieves plasma FIX levels of 400 ng/ml and 1.77 μg/ml at doses of 0.25 and 0.50 mg/kg, respectively, in KO mice.
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