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AdipoGen C12-L-HSL
Supplier: AdipoGen CDXD0335M005
Chemical. CAS 137173-46-7. Formula C16H29NO3. MW 283.4. Synthetic. N-Dodecanoyl-L-homoserine lactone C12-HSL is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-kappaB in RAW 264.7 macrophages, increasing the expression of TNF-alpha, interleukin-1beta IL-1beta and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte HaCaT cells. It is important to note that C12-HSL is distinct from N-3-oxo-dodecanoyl-L-homoserine lactone, which is produced at different times in biofilm development and has different cellular effects.
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