Sigma Aldrich C5 Lenalidomide-Piperazine-Pyridine-Alkyne-Nh2 Hydrochloride

Catalog No.	Quantity
91-772-950MG	500 mg

Catalog No. 91-772-950MG Supplier Sigma Aldrich Supplier No. 91772950MG

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Protein degrader building block C5 Lenalidomide-piperazine-pyridine-alkyne-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand with alternative exit vector, a rigid linker, and a pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC™ Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

• Quantity: 500 mg
• Synonym: 10-amino-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)decanamide hydrochloride; C5 Lenalidomide conjugate; Crosslinker-E3 ligase ligand conjugate; Protein degrader building block for PROTAC(R) research; Template for synthesis of targeted protein degrader