Sigma Aldrich C5 Lenalidomine-C3-Nh2 Hydrochloride

Catalog No.	Quantity
91-170-450MG	100 mg

Catalog No. 91-170-450MG Supplier Sigma Aldrich Supplier No. 91170450MG

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Protein degrader builiding block C5 Lenalidomide-C3-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand with alternative exit vector and an alkyl-chain crosslinker with pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands, warheads, and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Degrader Building Blocks for Targeted Protein DegradationBuilding PROTAC™ Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

• CAS: 375194-37-7
• Molecular Formula: C25H23OP
• Quantity: 100 mg
• Synonym: (S)-4-(Anthracen-9-yl)-3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole
• Molecular Weight (g/mol): 370.42 g/mol