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Medchemexpress LLC C6 Ceramide | 124753-97-5 | 99.8% | 397.63 | 25 MG
Supplier: Medchemexpress LLC 25MGHY19542
C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. It participates in the progression of multiple myeloma by suppressing the proliferation, migration, and angiogenesis of endothelial cells through targeting the Akt signal pathway. It also exhibits anti-cancer properties such as cell cycle arrest, apoptosis, inhibition of tumor growth, and enhances chemotherapy effects in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents to enhance anti-tumor effects.
- Enhances Trichostatin A (TSA)-induced cell death, apoptosis, and α-tubulin acetylation in CaOV3 and L3.6 cancer cells.
- Disrupts HDAC6/PP1/tubulin complex, leading to PP1 release and AKT dephosphorylation and inhibition.
- Increases miR29b expression and decreases Akt3, PI3K, and VEGFA expressions in HUVECs.
- Increases viable hippocampal neurons and enhances dendritic outgrowth in vitro.
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