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Apexbio Technology LLC C646 328968-36-1 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC B15775.1

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C646 (CAS 328968-36-1) is a small molecule pyrazolone derivative that functions as a selective competitive inhibitor of the histone acetyltransferase (HAT) activity of p300 It binds to the active site of p300 forming hydrogen bonds with residues Thr1411 Tyr1467 Trp1466 and Arg1410 C646 demonstrates a Ki of 400 nM and an IC50 of 1 6 M against p300 and also inhibits several p300 point mutants By specifically targeting p300-mediated protein acetylation C646 serves as a valuable research tool in studies investigating histone modification and gene transcription regulation

Catalog No. 50-000-62462


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