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Medchemexpress LLC CA-5f | 1370032-19-1 | 99.1% | 388.46 | 1 MG
Supplier: Medchemexpress LLC HY1126981MG
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor that works by inhibiting autophagosome-lysosome fusion. It increases LC3B-II (a marker for monitoring autophagy) and SQSTM1 protein levels, and also leads to increased ROS production. The compound has demonstrated anti-tumor activity.
- Potent late-stage macroautophagy/autophagy inhibitor.
- Inhibits autophagosome-lysosome fusion.
- Increases LC3B-II and SQSTM1 protein levels.
- Increases ROS production.
- Exhibits anti-tumor activity.
- Inhibits growth of A549 cells and is less cytotoxic to normal HUVECs in vitro.
- Well tolerated and potently inhibits tumor growth in nude mice bearing A549 lung cancer cells in vivo.
- Suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.
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