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Medchemexpress LLC CA-5f | 1370032-19-1 | 99.1% | 388.46 | 1 ML
Supplier: Medchemexpress LLC HY11269810MM/1ML
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor, working by inhibiting autophagosome-lysosome fusion. It increases LC3B-II and SQSTM1 protein levels and also increases ROS production, demonstrating anti-tumor activity.
- Potent late-stage macroautophagy/autophagy inhibitor
- Inhibits autophagosome-lysosome fusion
- Increases LC3B-II protein and SQSTM1 protein
- Increases ROS production
- Exhibits anti-tumor activity
- Inhibits the growth of A549 cells, and is less cytotoxic to normal HUVECs in vitro
- Does not impair the hydrolytic function or quantity of lysosomes in vitro
- Well tolerated and potently inhibits tumor growth in nude mice bearing A549 lung cancer cells in vivo
- Suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells in vivo
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