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Medchemexpress LLC CA-5f | 1370032-19-1 | 99.1% | 388.46 | 100 MG
SDP

Catalog No. 5000438419
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CA-5f is a potent late-stage macroautophagy/autophagy inhibitor that works by inhibiting autophagosome-lysosome fusion. It leads to an increase in LC3B-II (a marker for monitoring autophagy) and SQSTM1 protein levels, and also enhances ROS production. This compound demonstrates anti-tumor activity.

  • Potent late-stage macroautophagy/autophagy inhibitor.
  • Increases LC3B-II and SQSTM1 protein.
  • Increases ROS production.
  • Exhibits anti-tumor activity.
  • Well tolerated and potently inhibits tumor growth in nude mice bearing A549 lung cancer cells.
  • Suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.
  • Inhibits the growth of A549 cells and shows less cytotoxicity to normal HUVECs.
  • Does not impair the hydrolytic function or quantity of lysosomes.

Catalog No. 50-004-38419 Supplier Medchemexpress LLC Supplier No. HY112698100MG
May include imposed supplier surcharges.
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CA-5f is a potent late-stage macroautophagy/autophagy inhibitor that works by inhibiting autophagosome-lysosome fusion. It leads to an increase in LC3B-II (a marker for monitoring autophagy) and SQSTM1 protein levels, and also enhances ROS production. This compound demonstrates anti-tumor activity.

  • Potent late-stage macroautophagy/autophagy inhibitor.
  • Increases LC3B-II and SQSTM1 protein.
  • Increases ROS production.
  • Exhibits anti-tumor activity.
  • Well tolerated and potently inhibits tumor growth in nude mice bearing A549 lung cancer cells.
  • Suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.
  • Inhibits the growth of A549 cells and shows less cytotoxicity to normal HUVECs.
  • Does not impair the hydrolytic function or quantity of lysosomes.

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