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Medchemexpress LLC Ca/mao-b-in-1 | 98.3% | 345.37 | 1ML
Supplier: Medchemexpress LLC HY16338010MM/1ML
CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively. This compound demonstrates a human oral absorption of 71.9% based on in silico prediction.
- Dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B).
- IC50s are 8.8 nM for CA and 7.0 nM for MAO-B.
- Exhibits neuro- and mitochondrial protective effects against Aβ1-42 oligomer-induced neurotoxicity in SH-SY5Y cells.
- Reverts formation of reactive oxygen species (ROS).
- In silico prediction suggests 71.9% human oral absorption.
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