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Cayman Chemical CagrIlIntIdeacetate 10mg
Supplier: Cayman Chemical 4132910 MG
An amylin and calcitonin receptor agonist; binds to the AMY3 and calcitonin receptors (IC50s = 170 and 223 pM, respectively, for the human receptors); activates human AMY3 and calcitonin receptors in reporter assays (EC50s = 49 and 62 pM, respectively); increases cAMP accumulation in COS-1 cells expressing AMY1, AMY3, or calcitonin receptors (EC50s = 79.43, 114.82, and 43.65 nM, respectively); has a low propensity for inducing amyloid fibril formation with a lag time of 45 hours in a thioflavin T assay at 250 µM; reduces food intake in rats for at least 48 hours after a single dose of 3 or 30 nmol/kg; reduces body weight, food intake, and fat mass in a mouse model of diet-induced obesity at 100 nmol/kg
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