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MilliporeSigma™ Calbiochem™ 11beta-HSD1 Inhibitor, 10j

Catalog No. 38558110MG Shop All MilliporeSigma Products
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38-558-110MG 10 mg
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Description

The 11beta-HSD1 Inhibitor, 10j, also referenced under CAS 1009373-58-3, controls the biological activity of 11beta-HSD1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

A cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC50 of 1.6nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10mg/kg in animals p.o.) results in an ˜ 80% reduction in the concentration of plasma cortisol over vehicle treated controls.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 95% by HPLC
CAS 1009373-58-3
Molecular Formula C26H33BrN2O3
Formula Weight 501.46g/mol
Solubility DMSO
Form Solid
Quantity 10 mg
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