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MilliporeSigma™ Calbiochem™ 3,4-Dichloroisocoumarin

A potent irreversible inhibitor of serine proteases

Supplier:  MilliporeSigma™ 28781510MG

Catalog No. 28-781-510MG


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Description

Description

A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100μM.
Specifications

Specifications

Lyophilized Solid
10 mg
99% by elemental analysis
51050-59-0
215g/mol
Protect from moisture
White
serine proteases
C9H4Cl2O2
DMF or DMSO
SDS
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