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MilliporeSigma™ Calbiochem™ 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 μM).

Supplier:  MilliporeSigma™ 28789150MG

Catalog No. 28-789-150MG


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Description

Description

A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6μM). Reported to inhibit insulin-stimulated nuclear and cytosolic p70S6 kinase in CHO cells. Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. Induces G1/S cell cycle arrest.
Specifications

Specifications

Solid
White
casein kinase II
C12H12Cl2N2O4
DMSO or EtOH
50 mg
98% by TLC
53-85-0
319.2g/mol
SDS
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