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MilliporeSigma™ Calbiochem™ 7α, 25-dihydroxycholesterol

Catalog No. 1281361MG Shop All MilliporeSigma Products
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12-813-61MG 1 mg
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Catalog No. 12-813-61MG Supplier MilliporeSigma™ Supplier No. 1281361MG

Description

A highly potent and specific oxysterol EBI2 (GPR183) agonist with a kd of 450 pM in a saturation binding analysis, and activates EBI2 (EC50 140 pM compared wit

A highly potent and specific oxysterol EBI2 (GPR183) agonist with a kd of 450 pM in a saturation binding analysis, and activates EBI2 (EC50=140 pM compared with 2.1nM for its enantiomer 7b,25-OHC) in a GTP-γ assay. Dose-dependenty suppresses forskolin-induced cAMP accumulation in EBI2-expressing SK-N-MC/CRE-β galactosidase cell line with an IC50 of 2 nM, but not in control cells. Stimulates migration of LPS-activated spleen B cells and T cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells from EBI2-deficient mice.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 98% by HPLC
Molecular Formula C27H46O3
Formula Weight 418.3g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 1 mg
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