MilliporeSigma™ Calbiochem™ Calphostin C, Cladosporium cladosporioides

Description

A cell permeable, highly specific inhibitor of protein kinase C (IC₅₀ = 50nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters.

A cell permeable, highly specific inhibitor of protein kinase C (IC₅₀ = 50nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca²⁺ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC₅₀ > 5μM), protein kinase A (IC₅₀ > 50μM), protein kinase G (IC₅₀ > 25μM), and p60^{v- src} (IC₅₀ > 50μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.

Specifications

• Color: Light Brown
• Target Proteins: PKC
• CAS: 121263-19-2
• Molecular Formula: C₄₄H₃₈O₁₄
• Formula Weight: 790.8g/mol
• Solubility: DMSO or EtOH
• Content And Storage: Protect from light
• Form: Lyophilized
• Quantity: 50 μg
• Purity: 95% by HPLC