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  6. MilliporeSigma™ Calbiochem™ Calphostin C, Cladosporium cladosporioides

MilliporeSigma™ Calbiochem™ Calphostin C, Cladosporium cladosporioides

Catalog No. 20872550UG
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Quantity:
100 μg
50 μg

Description

A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters.

A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5μM), protein kinase A (IC50 > 50μM), protein kinase G (IC50 > 25μM), and p60v- src (IC50 > 50μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.
TRUSTED_SUSTAINABILITY

Specifications

Color Light Brown
Target Proteins PKC
CAS 121263-19-2
Molecular Formula C44H38O14
Formula Weight 790.8g/mol
Solubility DMSO or EtOH
Content And Storage Protect from light
Form Lyophilized
Quantity 50 μg
Purity 95% by HPLC
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