MilliporeSigma™ Calbiochem™ Cyclopamine, V. californicum

Description

Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog signaling through direct interaction with Smo.

A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. Also available as a 10mm solution in Ethanol (Cat. No. 239806).

Specifications

• Color: Off-white
• Target Proteins: Hh signaling in Shh-light2 assay
• CAS: 4449-51-8
• Molecular Formula: C₂₇H₄₁NO₂
• Formula Weight: 411.6g/mol
• Solubility: DMSO, EtOH, or DMF
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 1 mg
• Purity: 97% by HPLC