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MilliporeSigma™ Calbiochem™ Adenosine A2A Receptor Agonist I, CGS 21680, Hydrochloride

A xanthin derivative that acts as a potent agonist of adenosine A2A receptors (Ki =

Manufacturer:  MilliporeSigma™ 1191375MG

Catalog No. 11-913-75MG

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A xanthin derivative that acts as a potent agonist of adenosine A2A receptors (Ki = 27nM). Exhibits reduced affinity for A2B receptors (Ki = 67nM), but offers greater selectivity over A1R (Ki = 290nM) and A3R (88.8µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington's disease. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.


Supplied as a hydrochloride salt.
White solid
98% by HPLC
Protect from Light
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