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MilliporeSigma™ Calbiochem™ Adenosine Receptor Agonist, NECA

A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14 nM, 20 nM

Manufacturer:  MilliporeSigma™ 11914010MG

Catalog No. 11-914-010MG


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Description

Description

A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14 nM, 20 nM, 2.4µM and 6.2nM for A1, A2A, A2B, A3, respectively). Increases intracellular cAMP production (EC50 = 3.1µM in A2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.
Specifications

Specifications

99% by HPLC
Protect from Light
C12H16N6O4
DMSO
White solid
10mg
308.3g/mol
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