MilliporeSigma™ Calbiochem™ Lactacystin, Synthetic

Description

Lactacystin, Synthetic, CAS 1258004-00-0, is an irreversible inhibitor of 20S proteasome inhibitor (IC₅₀ = 500 nM). A covalent inhibitor of the chymotrypsin & trypsin-like activities of proteasome.

An irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC₅₀ = 500nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin- and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G₁ phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC₅₀ = 10μM).

Specifications

• Color: White
• Target Proteins: 20S proteasome (MCP; multicatalytic proteinase complex)
• CAS: 1258004-00-0
• Molecular Formula: C₁₅H₂₄N₂O₇S
• Formula Weight: 376.4g/mol
• Solubility: DMSO or H₂O
• Form: Solid
• Quantity: 400 μg
• Purity: 99% by HPLC