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  6. MilliporeSigma™ Calbiochem™ Lactacystin, Synthetic

MilliporeSigma™ Calbiochem™ Lactacystin, Synthetic

Catalog No. 426100400UG Shop All MilliporeSigma Products
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Catalog No. Quantity
42-610-0400UG 400 μg
42-610-0200UG 200 μg
42-610-01MG 1 mg
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Catalog No. 42-610-0400UG Supplier MilliporeSigma™ Supplier No. 426100400UG
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Description

Lactacystin, Synthetic, CAS 1258004-00-0, is an irreversible inhibitor of 20S proteasome inhibitor (IC50 = 500 nM). A covalent inhibitor of the chymotrypsin & trypsin-like activities of proteasome.

An irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin- and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10μM).
TRUSTED_SUSTAINABILITY

Specifications

Color White
Target Proteins 20S proteasome (MCP; multicatalytic proteinase complex)
CAS 1258004-00-0
Molecular Formula C15H24N2O7S
Formula Weight 376.4g/mol
Solubility DMSO or H2O
Form Solid
Quantity 400 μg
Purity 99% by HPLC
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