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  6. 12403310MG

MilliporeSigma™ Calbiochem™ Akt Inhibitor XVI, AT7867

Catalog No. 12403310MG
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Quantity:
10 mg

Description

A cell-permeable pyrazolo compound that acts as a potent inhibitor against Akt (IC50 = 32, 17, and 47nM against Akt1, Akt2, and Akt3, respectively), PKA (IC50 = 20nM), and p70S6K (IC50 = 85nM) in an ATP-competitive manner (Ki = 18nM using AKT2), with much reduced potency toward RSK1 (IC50 >100nM) and a panel of 13 other cellular kinases

A cell-permeable pyrazolo compound that acts as a potent inhibitor against Akt (IC50 = 32, 17, and 47nM against Akt1, Akt2, and Akt3, respectively), PKA (IC50 = 20nM), and p70S6K (IC50 = 85nM) in an ATP-competitive manner (Ki = 18nM using AKT2), with much reduced potency toward RSK1 (IC50 >100nM) and a panel of 13 other cellular kinases (IC50 >1μM). Shown to reduce cellular phosphorylation of GSK-3β (IC50 range from 2.08 to 4.45μM), S6R, FKHRL1, and inhibit the proliferation of cancer cells exhibiting constitutive Akt pathway activation both in vitro (IC50 range from 0.94 to 11.86μM) and in mice in vivo (20mg/kg via i.p. or 90mg/kg via p.o.).
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 99% by HPLC
Molecular Formula C20H20ClN3
Formula Weight 337.9g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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