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MilliporeSigma™ Calbiochem™ Akt Inhibitor XVI, AT7867

A cell-permeable pyrazolo compound that acts as a potent inhibitor against Akt (IC50 = 32, 17, and 47nM against Akt1, Akt2, and Akt3, respectively), PKA (IC50 = 20nM), and p70S6K (IC50 = 85nM) in an ATP-competitive manner (Ki = 18nM using AKT2), with much reduced potency toward RSK1 (IC50 >100nM) and a panel of 13 other cellular kinases (IC50

Manufacturer:  MilliporeSigma™ 12403310MG

Catalog No. 12-403-310MG


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Description

Description

A cell-permeable pyrazolo compound that acts as a potent inhibitor against Akt (IC50 = 32, 17, and 47nM against Akt1, Akt2, and Akt3, respectively), PKA (IC50 = 20nM), and p70S6K (IC50 = 85nM) in an ATP-competitive manner (Ki = 18nM using AKT2), with much reduced potency toward RSK1 (IC50 >100nM) and a panel of 13 other cellular kinases (IC50 >1μM). Shown to reduce cellular phosphorylation of GSK-3β (IC50 range from 2.08 to 4.45μM), S6R, FKHRL1, and inhibit the proliferation of cancer cells exhibiting constitutive Akt pathway activation both in vitro (IC50 range from 0.94 to 11.86μM) and in mice in vivo (20mg/kg via i.p. or 90mg/kg via p.o.).
Specifications

Specifications

99% by HPLC
Protect from Light
C20H20ClN3
DMSO
White powder
10mg
337.9g/mol
SDS
Documents
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