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MilliporeSigma™ Calbiochem™ Alendronate, Sodium Salt

An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.

Manufacturer:  MilliporeSigma™ 126855100MG

Catalog No. 12-685-5100MG


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Description

Description

An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). Efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70µM). Also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
Specifications

Specifications

98% by titration
Hygroscopic
Farnesyl diphosphate synthase
C4H12NNaO7P2·3H2O
H2O
White solid
100mg
121268-17-5
325.1g/mol
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