MilliporeSigma Calbiochem Alendronate, Sodium Salt
An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.
Manufacturer: MilliporeSigma 126855100MG
DescriptionAn amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). Efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70µM). Also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
|98% by titration|
|Farnesyl diphosphate synthase|
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