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MilliporeSigma™ Calbiochem™ Alendronate, Sodium Salt

Catalog No. 126855100MG Shop All MilliporeSigma Products
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Quantity:
100 mg

Description

An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.

An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). Efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ∽ 40 - 70μM). Also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ∽ 1 pM, in vitro invasion of prostate cancer cells).
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 98% by titration
Target Proteins Farnesyl diphosphate synthase
CAS 121268-17-5
Molecular Formula C4H12NNaO7P2·3H2O
Formula Weight 325.1g/mol
Solubility H2O
Content And Storage Hygroscopic
Form Solid
Quantity 100 mg
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