MilliporeSigma™ Calbiochem™ Rapamycin

Description

Rapamycin, CAS 53123-88-9, is an immunosuppressant that selectively inhibits mTOR and blocks the subsequent activation of p70 S6 kinase (IC₅₀ = 50 pM).

Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC₅₀ = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser⁴⁷³ appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110^Rb phosphorylation, p34^cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase. A 5mm (500μg/109μl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10mm (1mg/109μl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.

Specifications

• Color: Clear
• Target Proteins: Mammalian target of rapamycin (mTOR)
• CAS: 53123-88-9
• Molecular Formula: C₅₁H₇₉NO₁₃
• Formula Weight: 914.2g/mol
• Solubility: DMSO or MeOH
• Form: Film
• Quantity: 1 mg
• Purity: 99% by HPLC