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MilliporeSigma™ Calbiochem™ AMPK Signaling Activator XIII, ZLN005

Catalog No. 5043770001 Shop All MilliporeSigma Products
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50-437-70001 25 mg
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Description

Calbiochem AMPK Activator, CAS 4529-96-8, inhibits luciferase activity, and activates AMPK signaling.

A cell-permeable benzimidazole that, in addition to its inhibitory potency against luciferase activity (IC50 <10nM), also activates AMPK signaling by increasing cellular ADP/ATP ratio via mitochondria respiration upcoupling, effectively activating AMPK & PGC-1α in muscle, but not liver, cell types both in cultures (5-20μM in rat L6 myotubes) in vitro and in db/db mice (15mg/kg/day via p.o.) in vivo . Reported to improve glucose and insulin tolerance of db/db mice without any apparent effects on body weight or food intake.
TRUSTED_SUSTAINABILITY

Specifications

Color Pinkish-white
Description 99% by HPLC
Target Proteins increases cellular ADP/ATP ratio via mitochondria respiration uncoupling
Molecular Formula C17H18N2
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 25 mg
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