MilliporeSigma™ Calbiochem™ AMPK Signaling Activator XIII, ZLN005

Calbiochem AMPK Activator, CAS 4529-96-8, inhibits luciferase activity, and activates AMPK signaling.

Supplier:  MilliporeSigma™ 5.04377.0001

Catalog No. 50-437-70001

Description

A cell-permeable benzimidazole that, in addition to its inhibitory potency against luciferase activity (IC₅₀ <10nM), also activates AMPK signaling by increasing cellular ADP/ATP ratio via mitochondria respiration upcoupling, effectively activating AMPK & PGC-1α in muscle, but not liver, cell types both in cultures (5-20μM in rat L6 myotubes) in vitro and in db/db mice (15mg/kg/day via p.o.) in vivo . Reported to improve glucose and insulin tolerance of db/db mice without any apparent effects on body weight or food intake.

Specifications

• Color: Pinkish-white
• Target Proteins: increases cellular ADP/ATP ratio via mitochondria respiration uncoupling
• Solubility: DMSO
• Form: Powder

• Description: 99% by HPLC
• Molecular Formula: C₁₇H₁₈N₂
• Content And Storage: Protect from light
• Quantity: 25 mg