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MilliporeSigma™ Calbiochem™ AP-1/NF-κB Dual Inhibitor, SP100030

Catalog No. 5315350001 Shop All MilliporeSigma Products
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53-153-50001 10 mg
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Catalog No. 53-153-50001 Supplier MilliporeSigma™ Supplier No. 5315350001
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Description

A cell-permeable, non-toxic, conformationally restricted pyrimidinecarboxamide compound that acts as a potent, reversible T-cell specific inhibitor of both AP-1 and NF-κB transcriptional activation (IC50 = 50

A cell-permeable, non-toxic, conformationally restricted pyrimidinecarboxamide compound that acts as a potent, reversible T-cell specific inhibitor of both AP-1 and NF-κB transcriptional activation (IC50 = 50nM). Reduces DNA binding activity of NF-κB and downregulates NF-κB driven cytokine gene expression. Displays only trivial inhibitory effect against cytokine induction in a variety of other cells. Exhibits anti-inflammatory activity in a murine model of collagen-induced arthritis (∽ 10mg/kg/d, i.p.) and suppresses the expansion of AH-130 Yoshida ascites hepatoma in rats (∽ 5mg/kg/d, i.p.).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 95% by HPLC
Target Proteins AP-1 and NF-κB
Molecular Formula C14H5ClF9N3O
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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