MilliporeSigma™ Calbiochem™ AP-1/NF-κB Dual Inhibitor, SP100030

Description

A cell-permeable, non-toxic, conformationally restricted pyrimidinecarboxamide compound that acts as a potent, reversible T-cell specific inhibitor of both AP-1 and NF-κB transcriptional activation (IC₅₀ = 50

A cell-permeable, non-toxic, conformationally restricted pyrimidinecarboxamide compound that acts as a potent, reversible T-cell specific inhibitor of both AP-1 and NF-κB transcriptional activation (IC₅₀ = 50nM). Reduces DNA binding activity of NF-κB and downregulates NF-κB driven cytokine gene expression. Displays only trivial inhibitory effect against cytokine induction in a variety of other cells. Exhibits anti-inflammatory activity in a murine model of collagen-induced arthritis (∽ 10mg/kg/d, i.p.) and suppresses the expansion of AH-130 Yoshida ascites hepatoma in rats (∽ 5mg/kg/d, i.p.).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Specifications

• Color: Off-white
• Description: 95% by HPLC
• Target Proteins: AP-1 and NF-κB
• Molecular Formula: C₁₄H₅ClF₉N₃O
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 10 mg