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MilliporeSigma™ Calbiochem™ Argonaute-2 Inhibitor, BCI-137

Catalog No. 5315520001 Shop All MilliporeSigma Products
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53-155-20001 25 mg
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Catalog No. 53-155-20001 Supplier MilliporeSigma™ Supplier No. 5315520001
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Description

A cell-permeable, non-toxic dioxotetrahydroquinoxaline compound that mimics uridine and directly and reversibly interacts with the microRNA (miRNA) binding domain of Argonaute-2 (Ago2; KD = 126μM) and significantly inhibits binding of miR-20a, miR-26a, miR-107, miR-223, and let-7a to A

A cell-permeable, non-toxic dioxotetrahydroquinoxaline compound that mimics uridine and directly and reversibly interacts with the microRNA (miRNA) binding domain of Argonaute-2 (Ago2; KD = 126μM) and significantly inhibits binding of miR-20a, miR-26a, miR-107, miR-223, and let-7a to Ago2. However, it does not affect Ago2 stability in cells. Displaces Ago2 from the miR-155 host gene promoter region (70% reduction in Ago2 association) and increases histone H4 acetylation (∽300%) in NB4 leukemia cell line. Promotes retinoic acid-induced differentiation of NB4 cells to granulocytes.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
TRUSTED_SUSTAINABILITY

Specifications

Color Gray-white
Description 97% by HPLC
Target Proteins Argonaute-2
Molecular Formula C11H11N3O6S
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 25 mg
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