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MilliporeSigma™ Calbiochem™ ATIC Dimerization Inhibitor

Catalog No. 11849010MG Shop All MilliporeSigma Products
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11-849-010MG 10 mg
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Description

A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 2

A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 240nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (∽ 24 hours) compared to AICA-riboside (Cat. No. 123040).
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 97% by HPLC
Target Proteins ATIC
Molecular Formula C21H33N7O5
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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