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MilliporeSigma™ Calbiochem™ ATIC Dimerization Inhibitor

A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 2

Manufacturer:  MilliporeSigma™ 11849010MG

Catalog No. 11-849-010MG


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Description

Description

A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 240nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24 hours) compared to AICA-riboside (Cat. No. 123040).
Specifications

Specifications

97% by HPLC
Protect from Light
ATIC
DMSO
White solid
10mg
C21H33N7O5
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