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MilliporeSigma™ Calbiochem™ ATR Kinase Inhibitor II

A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12nM; Ki = 6nM) with excellent selectivity over ATM, DNA-PK (IC50 > 8µM) and in a 50-kinase panel (% inhibition at 2µM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKKα and FGFR3, resp

Manufacturer:  MilliporeSigma™ 11851010MG

Catalog No. 11-851-010MG


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Description

Description

A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12nM; Ki = 6nM) with excellent selectivity over ATM, DNA-PK (IC50 > 8µM) and in a 50-kinase panel (% inhibition at 2µM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKKα and FGFR3, respectively). Shown to block pH2AX-Ser139 (IC50 = 420nM in hydroxyurea treated HT29 cells) and preferentially enhance cisplatin (Cat. No. 232120) cytotoxicity against tumor cells over normal cells by ~7-fold at 620 nM.
Specifications

Specifications

97% by HPLC
Protect from Light
C22H25N5O3S
Yellow powder
10mg
DMSO
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