MilliporeSigma™ Calbiochem™ Autophagy Inhibitor IV, Cpd18

Description

A cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K

A cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation-induced autophagy at 1mm (IC₅₀ = 0.67 mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1mm at 12 hours compared with 72% reduction for 3-MA at 10 mM.

Please note that the molecular weight for this compound is lot-specific due to variable water content.

Specifications

• Color: White
• Description: 98% by HPLC
• Target Proteins: PI3K
• Molecular Formula: C₁₂H₁₇N₅
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 10 mg