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  6. 1968765MG

MilliporeSigma™ Calbiochem™ BAY 41-2272

Catalog No. 1968765MG Shop All MilliporeSigma Products
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Quantity:
5 mg

Catalog No. 19-687-65MG

Supplier: MilliporeSigma™ 1968765MG

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Description

A cell-permeable pyrazolopyridinylpyrimidine compound that acts as a selective and potent stimulator of soluble guanylate cyclase (effective dose ∽ 0.1nM to 100μM using recombinant soluble guanylate cyclase).

A cell-permeable pyrazolopyridinylpyrimidine compound that acts as a selective and potent stimulator of soluble guanylate cyclase (effective dose ∽ 0.1nM to 100μM using recombinant soluble guanylate cyclase). The mode of activation is NO-independent and appears to be mediated through direct binding to the α1 and α2 subunits. Shown to be effective in treating numerous cardiovascular conditions in animal models. Inhibits phenylephrine-induced constriction of rabbit aortic rings (IC50 = 304nM) and blocks collagen-induced aggregation of human platelets (IC50 = 36nM). Does not inhibit phosphodiesterases.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 98% by HPLC
Target Proteins Soluble guanylate cyclase
CAS 256376-24-6
Molecular Formula C20H17FN6
Formula Weight 360.4g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 5 mg
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