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MilliporeSigma™ Calbiochem™ Berberine Chloride

Catalog No. 20027525MG Shop All MilliporeSigma Products
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20-027-525MG 25 mg
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Catalog No. 20-027-525MG Supplier MilliporeSigma™ Supplier No. 20027525MG

Description

A highly potent and selective oxysterol EBI2 (GPR183) agonist (K

A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC50 = 140 pM over EC50 = 2.1nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC50 = 2nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4+ T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Description 95% by HPLC (NMR if no UV signal)
CAS 633-65-8
Molecular Formula C20H18NO4+Cl-
Formula Weight 371.81g/mol
Solubility DMSO or H2O
Content And Storage Protect from light
Form Powder
Quantity 25 mg
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