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MilliporeSigma™ Calbiochem™ BLM Helicase Inhibitor, ML216

Catalog No. 5063840001 Shop All MilliporeSigma Products
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50-638-40001 10 mg
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Catalog No. 50-638-40001 Supplier MilliporeSigma™ Supplier No. 5063840001
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Description

A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom's syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM636-1298 forms (IC50

A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom′s syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM636-1298 forms (IC50 = 2.98 and 0.97μM, respectively). Competes with and reversibly blocks DNA binding to BLM. However, the inhibition appears to be non-competitive with respect to ATP. Exhibits anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. Induces sister chromatid exchanges (SCEs) and enhances the sensitivity of BLM containing PSNF5 cells to aphidicolin (Cat. No. 178273) without affecting PSNG13 cells that are devoid of BLM. Displays favorable microsomal (T1/2 > 1.2 h) and plasma stability (∽100% at 5 h).
TRUSTED_SUSTAINABILITY

Specifications

Color Orange
Description 97% by HPLC
Target Proteins BLM
Molecular Formula C15H9F4N5OS
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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