MilliporeSigma™ Calbiochem™ Bortezomib

Description

Bortezomib, CAS 179324-69-7, is a cell-permeable, selective, slowly reversible inhibitor of 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity.

A cell-permeable dipeptidylboronate compound that selectively inhibits 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity ( k _inact/ K _i = 38,000, 5,700, and <100 M^-1s^-1, respectively, in human 20S proteasome assays using 10μM Suc-LLVY-AMC/Cat. No. 539142, 10μM Z-LLE-AMC/Cat. No. 539141, or 50μM Boc-LRR-AMC as substrate) via a covalent, slowly reversible manner, displaying much reduced potency against human chymotrypsin, cathepsin G, leukocyte elastase, and thrombin (K_i = 0.32, 0.63, 2.3, and 13μM, respectively, vs. 620nM using rabbit muscle 20S). A widely used inhibitor both in cultures in vitro and in animals in vivo .

Specifications

• Color: Off-white
• Description: 99% by HPLC
• Target Proteins: 20S proteasome
• Molecular Formula: C₁₉H₂₅BN₄O₄
• Formula Weight: 384.2g/mol
• Solubility: DMSO or EtOH
• Content And Storage: Hygroscopic, Protect from light
• Form: Solid
• Quantity: 5 mg