MilliporeSigma™ Calbiochem™ (+)-Brefeldin A, Eupenicillium brefeldianum

Description

Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function.

Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25mm solution in DMSO (Cat. No. 500583).

Specifications

• Color: White
• Description: 95% by HPLC
• Target Proteins: Blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus
• CAS: 20350-15-6
• Molecular Formula: C₁₆H₂₄O₄
• Formula Weight: 280.4g/mol
• Solubility: MeOH
• Form: Crystalline Solid
• Quantity: 1 mg