MilliporeSigma Calbiochem c-Raf Inhibitor
The c-Raf Inhibitor controls the biological activity of c-Raf. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
Manufacturer: MilliporeSigma 47595820MG
DescriptionA cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68µM) and WM3629 (GI50 = 0.86µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
|95% by HPLC|
|Off white solid|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok