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MilliporeSigma™ Calbiochem™ c-Raf Inhibitor

Catalog No. 47595820MG
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Quantity:
20 mg

Description

The c-Raf Inhibitor controls the biological activity of c-Raf. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68μM) and WM3629 (GI50 = 0.86μM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10μM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 95% by HPLC
Molecular Formula C23H19F3N8O
Formula Weight 480.45g/mol
Solubility DMSO
Form Solid
Quantity 20 mg
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