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MilliporeSigma™ Calbiochem™ c-Raf Inhibitor

The c-Raf Inhibitor controls the biological activity of c-Raf. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Manufacturer:  MilliporeSigma™ 47595820MG

Catalog No. 47-595-820MG


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Description

Description

A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68µM) and WM3629 (GI50 = 0.86µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
Specifications

Specifications

95% by HPLC
20mg
480.45g/mol
Off white solid
C23H19F3N8O
DMSO
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