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MilliporeSigma™ Calbiochem™ CaCC Blocker IV, Benzbromarone

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50-404-10001 100mg
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Description

A cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA (Cat

A cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA (Cat. No. 481987) and NPPB (Cat. No. 484100) in suppressing 500nM Ionomycin- (Cat. Nos. 407950, 407952, and 407953) induced I- influx in TMEM16A-expressing HEK293 cells (IC50 = 9.97, 140, and 150μM, respectively) as well as in blocking voltage-gated Cl- current in TMEM16B-expressing HEK293 cells, while exhibiting much reduced potency against ENaC (α, β, and γ) or CFTR. Shown to significantly reduce mucin secretion from NHBE (normal human bronchial epithelial) and suppress human ASM (airway smooth muscle) contraction upon muscarinic receptor stimulation.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 97% by HPLC
Target Proteins TMEM16A-CaCC
Molecular Formula C17H12Br2O3
Formula Weight 424.1g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 100 mg
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