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MilliporeSigma™ Calbiochem™ β-Catenin/Tcf Inhibitor VI, ICG-001

Catalog No. 5047120001 Shop All MilliporeSigma Products
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50-471-20001 10 mg
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Catalog No. 50-471-20001 Supplier MilliporeSigma™ Supplier No. 5047120001
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Description

A cell-permeable pyrazinopyrimidinecarboxamide that competes against β-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/β-catenin transcriptional regulations both in cultures in vitro (5 to 25μM) and in mice in vivo (5mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE c

A cell-permeable pyrazinopyrimidinecarboxamide that competes against β-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/β-catenin transcriptional regulations both in cultures in vitro (5 to 25μM) and in mice in vivo (5mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE complex. Shown to reactivate p300//TCF/β-catenin-mediated neuronal differentiation upon NGF stimulation in PS-1 L286V mutant-expressing PC-12 cultures and be efficacious in alleviating bleomycin- (0,08 units/50μL/mouse; administered intranasally; Cat. No. 203401) induced pulmonary fibrosis in mice.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 99% by HPLC
Target Proteins CREB-binding protein
Molecular Formula C33H32N4O4
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
Product Title
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