MilliporeSigma™ Calbiochem™ β-Catenin/Tcf Inhibitor VI, ICG-001

A cell-permeable pyrazinopyrimidinecarboxamide that competes against β-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/β-catenin transcriptional regulations both in cultures in vitro (5 to 25μM) and in mice in vivo (5mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE c

Supplier:  MilliporeSigma™ 5.04712.0001

Catalog No. 50-471-20001

Description

A cell-permeable pyrazinopyrimidinecarboxamide that competes against β-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/β-catenin transcriptional regulations both in cultures in vitro (5 to 25μM) and in mice in vivo (5mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE complex. Shown to reactivate p300//TCF/β-catenin-mediated neuronal differentiation upon NGF stimulation in PS-1 L286V mutant-expressing PC-12 cultures and be efficacious in alleviating bleomycin- (0,08 units/50μL/mouse; administered intranasally; Cat. No. 203401) induced pulmonary fibrosis in mice.

Specifications

• Color: Off-white
• Target Proteins: CREB-binding protein
• Solubility: DMSO
• Form: Powder

• Description: 99% by HPLC
• Molecular Formula: C₃₃H₃₂N₄O₄
• Content And Storage: Protect from light
• Quantity: 10 mg