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MilliporeSigma™ Calbiochem™ Cathepsin L Inhibitor, CAA0225

Catalog No. 2195021MG Shop All MilliporeSigma Products
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21-950-21MG 1 mg
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Description

An epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50

An epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro . During autophagy, it has been shown through immunoblotting that CAA0225 (10μg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 95% by HPLC
Molecular Formula C28H29N3O5
Formula Weight 487.55g/mol
Solubility DMSO
Form Solid
Quantity 1 mg
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