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MilliporeSigma™ Calbiochem™ CBFβ-Runx1 Inhibitor II, Ro5-3335

Catalog No. 21950610MG Shop All MilliporeSigma Products
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21-950-610MG 10 mg
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Description

A cell-permeable benzodiazepine that suppresses CBFα/Runx1-CBFβ transactivation activity (25μM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex

A cell-permeable benzodiazepine that suppresses CBFα/Runx1-CBFβ transactivation activity (25μM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Shown to inhibit oncogenic fusion CBFB-MYH11 -, TEL-RUNX1 -, and RUNX1-ETO -, dependent leukemia cells proliferation (IC50 = 1.1 to 21.7μM) in vitro and more effectively reduce peripheral blood c-kit+ population (300mg/kg/d via animal feed) than Cytarabine (Cat. No. 251010) in a murine Cbfb-MYH11 leukemia model in vivo . Comparing to CBFβ-Runx1 Inhibitor I (Cat. No. 219505), Ro5-3335 modulates the Runx1-CBFβ heterodimer formation without completely disrupting the subunits interaction.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by HPLC
Target Proteins RUNX1 and CBFβ
Molecular Formula C13H10ClN3O
Formula Weight 259.69g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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