MilliporeSigma™ Calbiochem™ CDC42 Inhibitor III, ZCL278

Description

A cell-permeable, non-cytotoxic, aqueous soluble (181μM in PBS, pH 7

A cell-permeable, non-cytotoxic, aqueous soluble (181μM in PBS, pH 7.4) pyrimidinylthiourea that targets Cdc42 GEF ITSN/intersectin and adjacent GTP/GDP binding site and effectively inhibits EGF-stimulated Cdc42 activity (1 h pretreatment; 50μM) and Cdc42-dependent microspike/filopodia formation in serum-starved Swiss 3T3 fibroblast cultures without affecting RhoA- or Rac1-dependent functions. Short-term ZCL278 exposure in primary murine neonatal cortical neurons is shown to dramatically abolish neurite branching (50μM).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

• Color: Light Beige
• Description: 94% by HPLC
• Target Proteins: CDC42
• Molecular Formula: C₂₁H₁₉BrClN₅O₄S₂
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 25 mg