MilliporeSigma™ Calbiochem™ CDC42 Inhibitor III, ZCL278
A cell-permeable, non-cytotoxic, aqueous soluble (181μM in PBS, pH 7
Supplier: MilliporeSigma™ 5.00503.0001
DescriptionA cell-permeable, non-cytotoxic, aqueous soluble (181μM in PBS, pH 7.4) pyrimidinylthiourea that targets Cdc42 GEF ITSN/intersectin and adjacent GTP/GDP binding site and effectively inhibits EGF-stimulated Cdc42 activity (1 h pretreatment; 50μM) and Cdc42-dependent microspike/filopodia formation in serum-starved Swiss 3T3 fibroblast cultures without affecting RhoA- or Rac1-dependent functions. Short-term ZCL278 exposure in primary murine neonatal cortical neurons is shown to dramatically abolish neurite branching (50μM).
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
|Protect from light|
|94% by HPLC|
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