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MilliporeSigma™ Calbiochem™ CFTR Activator, Cact-A1

Catalog No. 5059850001 Shop All MilliporeSigma Products
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50-598-50001 10 mg
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Catalog No. 50-598-50001 Supplier MilliporeSigma™ Supplier No. 5059850001
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Description

A cell-permeable, non-toxic aminopyrazolocarbonitrile compound that acts as a potent, selective, reversible and cAMP-independent activator of CFTR-dependent Cl- channel in airway epithelial cells (EC50

A cell-permeable, non-toxic aminopyrazolocarbonitrile compound that acts as a potent, selective, reversible and cAMP-independent activator of CFTR-dependent Cl- channel in airway epithelial cells (EC50 = 1.6μM in CFTR-expressing Fisher rat thyroid cells). Also shown to activate δF508-CFTR in primary CF-HBE cell cultures (EC50 = 3.5μM). Reported to directly bind to the same site as CFTRinh-172 ( Cat. No. 219670, Cat. No. 219674). Does neither elevate intracellular cAMP levels nor appear to have any requirement for cAMP agonist, such as forskolin (Cat. No. 344270, Cat. No. 344282). Shown to additively potentiate the G551D-CFTR Cl- current activated by forskolin with CFTR potentiator, VX-770. Exerts no effect on either Ca2+-activated Cl- channel (TMEM16A) or intracellular Ca2+ levels.
TRUSTED_SUSTAINABILITY

Specifications

Color Light Yellow
Description 98% by HPLC
Target Proteins CFTR
Molecular Formula C16H13N5O
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
Product Title
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