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MilliporeSigma™ Calbiochem™ CL-387,785

Catalog No. 2331001MG Shop All MilliporeSigma Products
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23-310-01MG 1 mg
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Description

A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity

A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC50 = 5nM). Blocks EGF-mediated growth in A431 cells. Inhibits proliferation of EGFR or c-ErbB2 expressing cells (IC50 = 31-125nM) by covalently binding to the EGFR.
TRUSTED_SUSTAINABILITY

Specifications

Color Pale Yellow
Description 95% by HPLC
Target Proteins EGFR kinase activity
CAS 194423-06-8
Molecular Formula C18H13BrN4O
Formula Weight 381.2g/mol
Solubility DMSO
Content And Storage Hygroscopic, Protect from light
Form Solid
Quantity 1 mg
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