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MilliporeSigma™ Calbiochem™ Combretastatin A-4

Catalog No. 23420010MG Shop All MilliporeSigma Products
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23-420-010MG 10 mg
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Description

A synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine tubulin binding and interferes with tubulin polymerization as well as cellular microtubule assembly

A synthetic Combretum caffrum -derived cell-permeable stilbenoid phenol that competes with colchicine (Cat No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1μM) and interferes with tubulin polymerization (IC50 = 2-3μM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 97% by HPLC
CAS 117048-59-6
Molecular Formula C18H20O5
Formula Weight 316.4g/mol
Solubility DMSO or EtOH
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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