MilliporeSigma™ Calbiochem™ D-Amino Acid Oxidase Inhibitor III, AS057278

Description

A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC₅₀ = 910nM against human DAO; [D-ser] = 10 mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50 mM) exposure (ED₅₀

A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC₅₀ = 910nM against human DAO; [D-ser] = 10 mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50 mM) exposure (ED₅₀ ≤3.95μM), while exhibiting little affinity toward NMDAR glycine binding site or inhibitory activity against D-aspartate oxidase (DDO/DSOX). Reported to be orally available and blood-brain barrier-permeant in rats and effectively prevent PCP (phencyclidine) from suppressing PPI (prepulse inhibition) response in mice (single 80mg/kg or 56X 20mg/kg/12 h b.i.d. oral dosages) in vivo .

Specifications

• Color: White
• Description: 99% by HPLC
• Target Proteins: DAAO
• CAS: 402-61-9
• Molecular Formula: C₅H₆N₂O₂
• Formula Weight: 126.11g/mol
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 50 mg